Verifiable Science

Age-related decreases in levels of several amino acids may influence cognitive function. Amino acids are important intermediates in the production of neurotransmitters in the brain and are involved in neuromodulating activities. L-tyrosine is an amino acid naturally synthesized in the body. It is the precursor of the neurotransmitters L-DOPA, dopamine, norepinephrine and epinephrine, supporting mood and mental clarity.1 DL-Phenylalanine provides a mixture of two essential amino acids, d-phenylalanine and l-phenylalanine. In the body l-phenylalanine converts to l-tyrosine, enhancing neurotransmitter support. A separate pathway allows both d- and l-phenylalanine to support levels of the mood-elevating compound phenylethylamine, a function not provided by l-tyrosine.2 The serotonin precursor l-tryptophan is included to support emotional well-being, relaxation and restful sleep. In a double-blind, placebo-controlled study, l-tryptophan supported healthy emotional processing and promoted positive outlook in women.3 Taurine is considered an inhibitory amino acid, helping to maintain healthy glutamate and other excitatory amino acid activity in the brain. This provides neuroprotective action important for maintaining healthy brain cell function.4 Acetyl-l-carnitine plays an important role in multiple metabolic and neurotransmitter systems in the brain, supporting memory, attention, mental clarity and mood.5‡